# Moderate tea consumption and dementia-related neuroimaging markers

## TL;DR

Moderate tea drinking is linked to better brain health and lower dementia risk, based on brain imaging and risk analysis in a large study.

## Contribution

This study shows a non-linear relationship between tea consumption and dementia risk using brain imaging and longitudinal data.

## Key findings

- Moderate tea consumption is positively associated with brain volumes in specific regions like the anterior parahippocampal gyrus.
- Daily consumption of 6-7 cups of tea is linked to reduced white matter hyperintensity and anterior cingulate cortex volumes.
- Tea consumption of 4-5 cups per day is associated with the lowest dementia risk compared to non-consumption.

## Abstract

Tea consumption may be associated with a reduced risk of dementia. However, the association between tea consumption and dementia-related neuroimaging markers remains unclear.

We analyzed 438,078 dementia-free participants from the UK Biobank at baseline, including 38,584 with complete brain imaging data. Linear regression models assessed brain imaging, Cox proportional hazards models evaluated dementia risk, and logistic regression analyzed cognitive decline. All analyses were adjusted for covariates and stratified by sex and age.

Moderate tea consumption was positively associated with regional brain volumes, including gray matter volume in the anterior parahippocampal gyrus, cuneal cortex, and the frontal lobe. Daily consumption of 6-7 cups of tea was significantly negatively associated with volumes of white matter hyperintensity (WMH) and the anterior cingulate cortex (ACC). Additionally, a significant association with the anterior parahippocampal gyrus was observed only in males. We found tea consumption showed a non-linear (p for non-linear < 0.0001) association with dementia. The lowest risk of incident dementia at a daily consumption level of 4–5 cups of tea (fully adjusted HR 0.804, 95% CI 0.752, 0.861) compared to non-consumption, consistent with the neuroimaging findings. No association was observed with cognitive decline.

Moderate tea consumption was associated with volumes in several brain regions and reduced risk of dementia. This study comprehensively demonstrates the consistent associations of moderate tea consumption with dementia risk and brain health, highlighting the potential benefits of moderate tea consumption in preventing dementia.