# Seasonal patterns in Bell's palsy: a systematic review and meta-analysis

## TL;DR

This study reviews and analyzes whether Bell's palsy cases vary by season, finding more cases in colder months.

## Contribution

The study provides a systematic review and meta-analysis to clarify seasonal patterns in Bell's palsy occurrence.

## Key findings

- Winter had the highest proportion of Bell's palsy cases (0.27), followed by autumn (0.26), spring (0.24), and summer (0.22).
- No statistically significant seasonal difference was confirmed, but colder months showed higher case numbers.
- The study highlights the need for further research in diverse climates to understand seasonal influences on Bell's palsy.

## Abstract

Bell's palsy (BP) is an idiopathic condition affecting the seventh cranial nerve, causing unilateral facial muscle paralysis. Conflicting reports exist on the impact of seasonal variations on BP, and limited systematic reviews have been conducted. In this study, a systematic review and meta-analysis of the BP literature was performed to assess the association between BP and the four seasons.

In accordance with PRISMA guidelines, a systematic search was performed using the PubMed, Google Scholar, and Web of Science databases to identify cohort studies reporting seasonal cases of idiopathic BP. Study quality and risk of bias were assessed via the Newcastle–Ottawa Scale (NOS). The associations between seasonal variations and the occurrence of BP were analyzed via a random effects model.

Eight cohort studies involving 3,363 BP patients were included, with a slight male predominance (51.5%). The pooled mean age was 44.72 ± 19.6 years. Pooled proportions for each season were determined via subgroup analysis. Winter proportions were the highest at 0.27 (95% CI: 0.24–0.31; I2 = 65.6%, p = 0.0048), followed by autumn at 0.26 (95% CI: 0.23–0.29; I2 = 59.3%, p = 0.0161). The spring proportion was 0.24 (95% CI: 0.20–0.27; I2 = 68.1%, p = 0.0026), whereas the summer proportion was 0.22 (95% CI: 0.19–0.25; I2 = 61.5%, p = 0.0111). The test for subgroup differences showed (χ2 = 6.62, p = 0.0850).

BP cases were more common during colder months than during warmer months. Although no statistically significant association was found, this highlights the need for further studies across diverse climatic regions to clarify potential seasonal influences.

https://www.crd.york.ac.uk/PROSPERO/view/CRD42024623519, identifier: CRD42024623519.