# Association of preoperative controlling nutritional status score with clinical outcomes among surgical patients with esophageal cancer: a meta-analysis

## TL;DR

This study finds that a higher preoperative CONUT score is linked to worse outcomes in patients undergoing surgery for esophageal cancer.

## Contribution

The study provides new evidence that the preoperative CONUT score is a reliable predictor of both long-term and short-term outcomes in esophageal cancer surgery.

## Key findings

- Higher CONUT scores are associated with significantly worse overall, disease-free, and cancer-specific survival.
- Elevated CONUT scores correlate with increased risks of postoperative complications like pneumonia and respiratory issues.
- Subgroup analyses confirm these associations across different treatment and pathology types.

## Abstract

The aim of this study was to identify the relationship between preoperative controlling nutritional status (CONUT) score and long-term and short-term outcomes in patients with esophageal cancer receiving esophagectomy.

The Web of Science, EMBASE, PubMed, and CNKI databases were searched up to 24 January 2025. Primary outcome was long-term survival such as the overall survival (OS), disease-free survival (DFS), and cancer-specific survival (CSS). Secondary outcomes included the postoperative overall complication, incision infection, anastomotic fistula, pneumonia, respiratory complication, 90-day death, cardiovascular complication, major adverse cerebrocardiovascular event (MACCE), pulmonary atelectasis, and pulmonary embolism. Hazard ratio (HR) and odds ratio (OR) with 95% confidence interval (CI) were separately combined for the primary and secondary outcomes. Subgroup analysis for the OS and DFS by neoadjuvant therapy and pathological type was further conducted.

Eighteen studies with 5,495 cases were included. Pooled results manifested that elevated preoperative CONUT score predicted significantly worse OS (HR = 1.75, 95% CI: 1.30–2.37, p<0.001), DFS (HR=1.21, 95% CI: 1.13–1.30, p < 0.001), and CSS (HR = 2.60, 95% CI: 1.65–4.10, p<0.001). Subgroup analysis for the OS and DFS by the history of neoadjuvant therapy and pathological type demonstrated similar results. Furthermore, elevated CONUT score was significantly related to increased risk of overall complication (OR = 1.50, 95% CI: 1.14–1.96, p=0.004), pneumonia (OR= 1.60, 95% CI: 1.23–2.08, p<0.001), respiratory complication (OR = 1.60, 95% CI: 1.26–2.03, p<0.001), cardiovascular complication (OR = 3.660, 95% CI: 1.068–12.550, p=0.039), MACCE (OR = 1.920, 95% CI: 1.068–3.452, p=0.040), and pulmonary atelectasis (OR = 2.314, 95% CI: 1.408–3.805, p<0.001).

Preoperative CONUT score might serve as a prognostic indicator in surgical esophageal cancer, and patients with elevated CONUT score are suggested to experience worse long-term and short-term clinical outcomes.