# Effect of Different Matrix Metalloproteinase Inhibitors on the Shear Bond Strength of Composite Attached to Dentin: An In Vitro Study on Permanent Teeth

## TL;DR

This study tested how different inhibitors affect the bond strength of dental composites to dentin, finding that Gluma desensitizer was the most effective.

## Contribution

The study compares the effectiveness of various MMP inhibitors on composite bond strength to dentin using an in vitro method.

## Key findings

- Gluma desensitizer showed the highest bond strength (12.98 MPa) compared to other groups.
- Pretreatment with MMP inhibitors significantly improved shear bond strength (P < 0.05).

## Abstract

Aim: This study aimed to evaluate the effect of various matrix metalloproteinase (MMP) inhibitors on the shear bond strength (SBS) of composite resin to dentin in permanent teeth using an etch-and-rinse adhesive system and the pairwise comparative analysis between each MMP inhibitor group and the control group.

Materials and methods: Dentin blocks were prepared from 60 permanently extracted molars and were randomly distributed into four groups (each group, n = 15). The dentinal blocks were pretreated with 0.01M phosphate-buffered saline (PBS) (pH 7.2) in the control group (Group I), 2% chlorhexidine (CHX) (Group II), Gluma desensitizer (Kulzer, Germany) (Group III), and 6.5% proanthocyanidin (Group IV) before applying the etch and rinse adhesive system (Ivoclar, Switzerland). After the adhesive application, composite resin (Kulzer, Germany) was applied, and after seven days, the SBS values were determined with a Universal Testing Machine (Zwick/Roell Z020, ZwickRoell Group, Germany).

Results: There was a significant difference in the SBS values of Gluma desensitizer, 2% CHX, 6.5% proanthocyanidin, and the control group (P < 0.05). The Gluma desensitizer group showed the highest bond strength values (mean 12.98 MPa), which were significantly greater than those of all the other groups.

Conclusions: Under the experimental conditions of this study, pretreatment with MMP inhibitors was advantageous in improving the SBS of the composite attached to permanent teeth dentin, with Gluma being most effective.