# Rapid access to the core of malayamycin A by intramolecular dipolar cycloaddition

## TL;DR

A new chemical method efficiently builds the core structure of malayamycin A and similar compounds, which could lead to better fungicides.

## Contribution

A streamlined, alkene-free approach using intramolecular dipolar cycloaddition to access the core of malayamycin A and related uracil nucleosides.

## Key findings

- The oxazoline-based latent functionality strategy successfully unmasked the 1,2-hydroxyamine moiety.
- The method avoids alkene functionalization, simplifying prior synthetic routes.
- The approach enables the synthesis of diverse uracil nucleosides and derivatives for fungicide development.

## Abstract

We have streamlined a dipolar cycloaddition approach to assemble the core of malayamycin A and other related uracil nucleosides possessing the common bicyclic perhydrofuropyran framework. The latent functionality strategy employing oxazoline to unmask the 1,2-hydroxyamine moiety proves feasible, eliminating the need for alkene functionalization required in previous endeavours. This current strategy provides a reliable platform for accessing diverse uracil nucleosides and their derivatives, facilitating the development of potent fungicides.