# Knee Health Is a Major Determinant of Mobility Across the Healthspan

## TL;DR

Knee health significantly affects mobility and overall physical function across a person's lifetime.

## Contribution

This review provides a comprehensive synthesis of the interconnected factors influencing knee health and mobility.

## Key findings

- Knee impairments cause biomechanical and physiological changes affecting mobility.
- Knee health involves dynamic interactions between structure, neuromuscular function, and biomechanics.
- Understanding these relationships is key to developing interventions that preserve mobility.

## Abstract

Knee health constitutes a pivotal determinant of locomotor function and overall mobility throughout the healthspan. Impairments in knee function lead to a series of biomechanical and physiological alterations that pose substantial public health challenges and economic burdens worldwide. This review synthesizes evidence that delineates the complex and multifaceted relationship between knee health and mobility, emphasizing the interplay across various domains in adult populations. Knee health is conceptualized as a dynamic, interconnected system whereby structural integrity, neuromuscular mechanisms, biomechanical adaptations, and functional mobility are intricately interrelated through cascades of mechanistic processes operating across different temporal stages. A comprehensive understanding of these interrelationships is necessary for developing precise and targeted interventions that aim to preserve mobility and functional independence throughout the healthspan.