# Prolonged Survival with Dieting for Improved Autophagy

## TL;DR

Dieting and nutrition that improve autophagy and AMPK signaling may help extend lifespan and reduce aging-related diseases.

## Contribution

The paper proposes that modulating AMPK through diet and non-coding RNAs could be a novel therapeutic strategy for longevity.

## Key findings

- AMPK signaling is crucial for autophagy and lifespan regulation.
- Dietary interventions and nutraceuticals can modulate AMPK and autophagy.
- Non-coding RNAs and gut microbiota changes may influence autophagy through diet.

## Abstract

Food is a crucial component affecting the health of individuals, which may have the potential to expand lifespan. It has been shown that a long lifespan may be related to fine-tuned autophagy. In general, suitable autophagy could play a significant role in the anti-aging biological exertion of the host. AMPK, a member of serine and threonine kinases, could play vital roles within the autophagy signaling pathway in various cells. In addition, alterations in the kinase activity of AMPK have been shown to be connected to several pathologies of aging-related diseases. Therefore, autophagy could control the lifespan-related homeostasis within the host from cells to a body via the modification of AMPK. The design of the diet and/or nutrition targeting the AMPK would be a possibility to expand the lifespan. Some analyses of the molecular biology underlying the autophagy suggest that supplementation of accurate nutraceuticals, as well as dietary restriction, mild fasting, and/or appropriate physical exercise, could modulate AMPK signaling, which may be advantageous for life extension with the alteration of autophagy. Remarkably, it has been revealed that several non-coding RNAs (ncRNAs) might also play significant roles in the regulation of autophagy. In addition, the production of some ncRNAs may be associated with the alteration of gut microbiota with certain diets. Therefore, the modulation of AMPK action with ncRNAs through choosing the relevant diet could be a therapeutic tactic for promoting longevity, which is also accompanied by a reduced risk for several aging-related diseases.