# Cardiovascular manifestations in mast cell activation disease: key insights for cardiologists and angiologists

## TL;DR

Mast cell activation disease can affect the cardiovascular system, and cardiologists should be aware of its symptoms and challenges.

## Contribution

This review provides key insights into the cardiovascular manifestations of mast cell activation disease for clinicians.

## Key findings

- Mast cell activation disease has cardiovascular manifestations due to mediator release and mast cell accumulation.
- The disease is highly prevalent, with up to 17% affected, yet often unrecognized in clinical practice.
- Cardiologists and angiologists need to be knowledgeable about this condition to manage its cardiovascular challenges.

## Abstract

Mast cell activation disease is a genetic disease entity characterized by a very pronounced clinical symptomatology with potential manifestations in virtually every organ and tissue. These arise from the inappropriate release of mast cell mediators and the accumulation of both morphologically normal and mutated mast cells. Owing to the high prevalence of the disease—estimated to be up to 17%—cardiologists and angiologists are frequently confronted with mast cell activation disease in their daily clinical practice, often without recognizing it. Therefore, every cardiologist and angiologist should possess basic knowledge about this disease and be aware of its cardiovascular challenges. This review summarizes the current state of knowledge on this highly complex disease, with a particular focus on the cardiovascular aspects.