# Laparoscopic hepaticopancreaticoduodenectomy for synchronous intrahepatic cholangiocarcinoma and distal common bile duct tumors: a case report

**Authors:** Yuhui Fang, Dongdong Huang, Yuquan Chang, Qijie Luo, Ruiqin Huang, Kun He

PMC · DOI: 10.3389/fonc.2025.1665399 · Frontiers in Oncology · 2025-11-10

## TL;DR

This case report describes a successful laparoscopic surgery for a rare combination of bile duct tumors in a patient's liver and bile duct.

## Contribution

The novelty lies in reporting a successful LHPD case for synchronous intrahepatic and distal bile duct tumors with no major postoperative complications.

## Key findings

- A 53-year-old female underwent successful LHPD for combined intrahepatic and common bile duct tumors.
- The patient was discharged without bile or pancreatic fistula on postoperative day 13.
- Pathology confirmed tubular adenoma with high-grade intraepithelial neoplasia in both locations.

## Abstract

Laparoscopic hepatopancreatoduodenectomy (LHPD) is a while very complex procedure for biliary malignancies combined with intrahepatic bile duct invasion, but there are few reports of related surgeries due to high postoperative complications and mortality. In this study, we report a case of tubular adenoma with high-grade intraepithelial neoplasia of the homologous left hepatic bile duct combined with the common bile duct.

A 53-year-old female was admitted to the hospital with jaundice for one week. Imaging studies showed space-occupying lesions in both the left intrahepatic and common bile duct. We performed LHPD, and the patient was discharged on postoperative day 13 without bile and pancreatic fistula. Pathology confirmed tubular adenoma with high-grade intraepithelial neoplasia in both sites.

LHPD can be an option for radical surgery in carefully screened patients with biliary malignancies with intrahepatic invasion.

## Linked entities

- **Diseases:** intrahepatic cholangiocarcinoma (MONDO:0003210), tubular adenoma (MONDO:0024660)

## Full-text entities

- **Diseases:** pancreatic fistula (MESH:D010185), bile and (MESH:D001649), distal common bile duct tumors (MESH:D003138), intrahepatic cholangiocarcinoma (MESH:D018281), biliary malignancies (MESH:D009369), intraepithelial neoplasia (MESH:D002578), jaundice (MESH:D007565), adenoma (MESH:D000236)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

31 references — full list in the complete paper: https://tomesphere.com/paper/PMC12641395/full.md

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Source: https://tomesphere.com/paper/PMC12641395