# Case Report: ProRoot MTA degradation in a compromised tooth: secondary trauma and acidic microenvironment leading to retreatment with Biodentine

**Authors:** Saulius Drukteinis, Goda Bilvinaitė, Kerstin Galler

PMC · DOI: 10.3389/fdmed.2025.1686600 · Frontiers in Dental Medicine · 2025-11-06

## TL;DR

A case report shows how ProRoot MTA degraded in a traumatized tooth with an acidic environment, leading to retreatment with Biodentine for successful healing.

## Contribution

First documented case linking secondary trauma-induced acidity to ProRoot MTA degradation in orthodontically compromised teeth.

## Key findings

- ProRoot MTA degraded over 18 months in a tooth with acidic microenvironment and secondary trauma.
- Biodentine retreatment resulted in complete periapical healing and symptom resolution.
- Biodentine is suggested as a more pH-resistant alternative for compromised dental cases.

## Abstract

Dental trauma can jeopardize the long-term success of previous endodontic treatments, especially in teeth affected by orthodontically induced inflammatory root resorption (OIIRR). This case presents the first documented association between secondary trauma-induced acidity and degradation of ProRoot mineral trioxide aggregate (MTA) in such compromised teeth.

A 20-year-old male with a history of orthodontic treatment and severe apical root resorption sustained a subluxation injury to tooth 22, leading to pulp necrosis and apical pathosis. Initial endodontic management with ProRoot MTA achieved favorable outcomes at 6- and 18-month follow-ups. Two-and-a-half years later, secondary trauma occurred. Over the following 18 months, the tooth developed acute symptoms, a periapical lesion, and radiographic signs of MTA disintegration. Endodontic retreatment with Biodentine resolved the symptoms and achieved complete periapical healing, confirmed at 3, 6, and 18 months, and 4 years post-treatment.

This case highlights MTA's susceptibility to acidic degradation in compromised conditions and supports Biodentine as a potentially more pH-resistant alternative. Clinicians should be vigilant when treating traumatized, orthodontically compromised teeth and prioritize restorative materials with high stability in hostile environments to minimize treatment failure risk.

## Linked entities

- **Diseases:** pulp necrosis (MONDO:0001326)

## Full-text entities

- **Diseases:** pulp necrosis (MESH:D003790), periapical lesion (MESH:D010483), subluxation injury (MESH:D004204), apical pathosis (MESH:D010485), Dental trauma (MESH:D014947), OIIRR (MESH:D012391)
- **Chemicals:** ProRoot (-), MTA (MESH:C086631), Biodentine (MESH:C506393)

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12641284/full.md

## References

21 references — full list in the complete paper: https://tomesphere.com/paper/PMC12641284/full.md

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Source: https://tomesphere.com/paper/PMC12641284