# A continuous flow process for the Ireland–Claisen rearrangement

## TL;DR

A new continuous flow method enables efficient and stereocontrolled synthesis of complex molecules at room temperature.

## Contribution

The study introduces a continuous flow process for enantioselective Ireland–Claisen rearrangement at room temperature.

## Key findings

- The reaction achieved stereocontrolled synthesis of vicinal stereogenic centers without cryogenic conditions.
- The process showed minimal loss in yield or optical purity during synthesis.
- The reaction scope was validated through the synthesis of several allyl esters.

## Abstract

Herein, we describe an in-depth study of an enantioselective Ireland–Claisen rearrangement using a continuous flow reactor. The use of this innovative technology led to a rapid reaction at room temperature, enabling the stereocontrolled synthesis of vicinal stereogenic centers with little to no loss in yield or optical purity, in the absence of cryogenic conditions. The reaction scope was examined via the synthesis of several allyl esters, and the results were discussed. The validation and scale-up of the process were also performed.

The transposition of an enantioselective Ireland–Claisen rearrangement was performed in a continuous flow reactor with a short residence time, achieving great stereocontrolled syntheses of vicinal stereogenic centers at room temperature.