# High Prevalence of Cold Intolerance in Rheumatoid Arthritis: A Case–Control Study

**Authors:** Mohsen Soroush, Rojin Farzaneh, Elaheh Babapour, Amirreza Jabbaripour Sarmadian, Sami Rassouli, Golrokh Hassanzadeh Behrouz, Amirreza Naseri, Maryam Mahmoudi, Kamal Esalatmanesh, Aida Malek Mahdavi, Alireza Khabbazi

PMC · DOI: 10.1002/ccr3.71502 · Clinical Case Reports · 2025-11-23

## TL;DR

Rheumatoid arthritis patients often experience cold intolerance, which worsens their quality of life and is linked to disease duration and symptoms.

## Contribution

This study identifies cold intolerance as a prevalent and impactful symptom in rheumatoid arthritis patients.

## Key findings

- Cold intolerance is more common in rheumatoid arthritis patients compared to controls.
- It is associated with longer disease duration and symptoms like pain and swelling.

## Abstract

Cold intolerance is more common in rheumatoid arthritis patients than control. Cold intolerance tends to develop after rheumatoid arthritis onset and is associated with longer disease duration, with pain and swelling being dominant features. Cold intolerance leads to a reduced quality of life in rheumatoid arthritis patients.

## Linked entities

- **Diseases:** rheumatoid arthritis (MONDO:0008383)

## Full-text entities

- **Diseases:** swelling (MESH:D004487), Rheumatoid Arthritis (MESH:D001172), Cold Intolerance (MESH:D000067390), pain (MESH:D010146)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

45 references — full list in the complete paper: https://tomesphere.com/paper/PMC12640793/full.md

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Source: https://tomesphere.com/paper/PMC12640793