# Primary Burkitt Lymphoma of the Thyroid Gland With Underlying Hashimoto’s Thyroiditis: A Case Report

**Authors:** Dhruvin Shah, Narendra Hirani, Ajeet K Khilnani, Rashmi Sorathiya, Nikita Modh

PMC · DOI: 10.7759/cureus.95155 · Cureus · 2025-10-22

## TL;DR

A rare case of thyroid Burkitt lymphoma in a man with Hashimoto’s thyroiditis was successfully treated with chemotherapy.

## Contribution

This case report adds to the limited literature on primary thyroid Burkitt lymphoma and its association with Hashimoto’s thyroiditis.

## Key findings

- A 30-year-old male with rapidly progressive thyroid swelling was diagnosed with primary Burkitt lymphoma.
- Treatment with R-CHOEP chemotherapy led to complete remission after three months.
- The case emphasizes the need for early diagnosis and prompt treatment for this aggressive malignancy.

## Abstract

Primary Burkitt lymphoma of the thyroid is an exceptionally rare, highly aggressive B-cell malignancy. We present the case of a 30-year-old male with a rapidly progressive anterior neck swelling. Imaging revealed a large left thyroid mass with cervical lymphadenopathy, and fine needle aspiration cytology was suspicious for malignancy. Total thyroidectomy was performed, and histopathology and immunohistochemistry confirmed Burkitt lymphoma. The patient received three cycles of R-CHOEP (rituximab, cyclophosphamide, vincristine, adriamycin, etoposide, and prednisolone) chemotherapy, and follow-up positron emission tomography-computed tomography after three months demonstrated complete remission. This case highlights the importance of early diagnosis and prompt chemotherapy in achieving favorable outcomes for this rare entity.

## Linked entities

- **Chemicals:** cyclophosphamide (PubChem CID 2907), vincristine (PubChem CID 5978), adriamycin (PubChem CID 31703), etoposide (PubChem CID 36462), prednisolone (PubChem CID 5755)
- **Diseases:** Burkitt lymphoma (MONDO:0007243), Hashimoto’s thyroiditis (MONDO:0007699)

## Full-text entities

- **Diseases:** Hashimoto's Thyroiditis (MESH:D050031), malignancy (MESH:D009369), thyroid mass (MESH:C536030), anterior neck swelling (MESH:D019547), Burkitt Lymphoma of the Thyroid (MESH:D002051), cervical lymphadenopathy (MESH:D002575), B-cell malignancy (MESH:D016393)
- **Chemicals:** R-CHOEP (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12640417/full.md

## References

18 references — full list in the complete paper: https://tomesphere.com/paper/PMC12640417/full.md

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Source: https://tomesphere.com/paper/PMC12640417