# Reverse Takotsubo Cardiomyopathy in a Woman With Clostridioides difficile Colitis and a Sepsis-Like Syndrome: A Case Study

**Authors:** Naomi R Khanna, Adil Pervaiz

PMC · DOI: 10.7759/cureus.97512 · Cureus · 2025-11-22

## TL;DR

An elderly woman with a severe gut infection and sepsis-like symptoms developed a rare heart condition called reverse Takotsubo cardiomyopathy, which was diagnosed and treated with supportive care.

## Contribution

This case study adds to the limited understanding of reverse Takotsubo cardiomyopathy in the context of sepsis and gastrointestinal infections.

## Key findings

- Reverse Takotsubo cardiomyopathy was diagnosed in a 74-year-old woman with Clostridioides difficile colitis and sepsis-like syndrome.
- Supportive therapy led to recovery after the condition was identified through echocardiography and cardiac catheterization.
- The case emphasizes the importance of recognizing stress-induced cardiomyopathies in critically ill patients.

## Abstract

In this report, we present a case of reverse Takotsubo cardiomyopathy (rTTC) in an elderly female, 74 years old, with Clostridioides difficile colitis and sepsis-like features complicated by hypotension and arrhythmias. The diagnosis was eventually established through echocardiography and cardiac catheterization. Supportive therapy favored recovery after diagnosis. This case of rTTC highlights a serious, although rare, cardiac condition that emphasizes the importance of workup and recognition to support optimal management and recovery and underscores the need to keep stress-induced cardiomyopathies in mind in critically ill patients.

## Full-text entities

- **Diseases:** Sepsis-Like Syndrome (MESH:D018746), cardiomyopathies (MESH:D009202), cardiac condition (MESH:D006331), sepsis (MESH:D018805), hypotension (MESH:D007022), arrhythmias (MESH:D001145), Clostridioides difficile Colitis (MESH:D003015), Takotsubo Cardiomyopathy (MESH:D054549)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12640221/full.md

## References

6 references — full list in the complete paper: https://tomesphere.com/paper/PMC12640221/full.md

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Source: https://tomesphere.com/paper/PMC12640221