# Myocardial enzyme profile and short-term prognosis of patients with prolonged myocardial damage after transcatheter aortic valve replacement

## TL;DR

This study examines how heart enzyme levels and short-term outcomes differ in patients with heart damage after a specific heart valve surgery.

## Contribution

The study identifies that increased myocardial enzyme levels after TAVR may indicate heart damage and are linked to higher bleeding risks.

## Key findings

- Myocardial enzyme levels increased significantly in patients with post-TAVR myocardial damage.
- Patients with myocardial damage had a higher incidence of postoperative bleeding.
- Elevated CK-MB and cTnT levels may serve as indicators of postoperative myocardial damage.

## Abstract

This work investigated the changes in myocardial enzyme profile (MEP) and short-term prognosis (STP) in patients with myocardial damage (MD) after transcatheter aortic valve replacement (TAVR).

100 patients receiving TAVR surgery were selected and rolled into an observation group (Obs group, 50 cases) and a control group (Ctrl group, 50 cases) according to postoperative myocardial status. The changes in MEP before and after the TAVR and the STP within 3 days after surgery were compared and analysed.

Creatine Kinase MB (CK-MB) levels were (21.6±8.8) IU/L, (17.2±7.1) IU/L, and (15.2±6.4) IU/L at 12 h, 24 h, and 72 h after TAVR, respectively, in the Obs group; and the cTnT levels were (0.284±0.13) ng/mL, (0.315±0.15) ng/mL, and (0.363±0.22) ng/mL, respectively, at the same time points. The CK-MB and cTnT levels in the Obs group were increased more obviously based on the conditions in the Ctrl group (P<0.05). After surgery, 23 cases of bleeding occurred in the Obs group, significantly more than 8 cases in the Ctrl group (P<0.05). Differences in ultrasonic test results were not obvious (P>0.05).

The MEP of patients after TAVR generally increased, and the increase in the degree of patients with MD was more significant, which may be an indicator to judge the postoperative MD. Patients with postoperative MD had a higher probability of postoperative bleeding.