# Serum level of (interleukin (IL)-2, IL-10, tumor necrosis factor (TNF)-a, motilin (MTL), gastrin (GAS), pepsinogen (PG), after adjunctive treatment in patients with chronic atrophic gastritis

## TL;DR

This study shows that combining TCM matrine with omeprazole improves stomach health and reduces inflammation in patients with chronic atrophic gastritis.

## Contribution

The study demonstrates that matrine combined with omeprazole improves histopathology and gastric function in CAG patients.

## Key findings

- Patients treated with matrine and omeprazole had lower histopathological scores compared to those with omeprazole alone.
- The combination therapy reduced inflammatory cytokine levels like IL-2, IL-10, and TNF-a more effectively.
- The treatment improved H. pylori eradication rates and overall clinical efficacy.

## Abstract

The study aimed to demonstrate the impact of traditional Chinese medicine (TCM) matrine combined with omeprazole enteric-coated tablets on gastric mucosal histopathology, gastric function, inflammatory cytokines, and Helicobacter pylori (H. pylori) eradication in patients with chronic atrophic gastritis (CAG).

A retrospective collection of case data from 110 patients with CAG admitted to the TCM Department of the hospital was conducted. Patients were rolled into the test group (TG, matrine + omeprazole enteric-coated tablets) and the control group (CG, omeprazole enteric-coated tablets). The gastric mucosal histopathological scores, serological indicators (interleukin (IL)-2, IL-10, tumour necrosis factor (TNF-a), gastric function (motilin (MTL), gastrin (GAS), pepsinogen (PG)), H. pylori eradication rate, and clinical efficacy were compared.

The degree of glandular atrophy, intestinal meta-plasia, dysplasia, and inflammatory activity index in patients of TG post-treatment were lower than CG (P<0.05). Post-treatment, IL-2, IL-10, and TNF-a levels in patients of TG were inferior to CG (P<0.05), and the H. pylori eradication rate in patients of TG (87.27%) was inferior to CG (63.64%) (P<0.05). The effective treatment rate in patients of TG post-treatment (92.73%) was higher than CG (78.18%) (P<0.05).

Matrine combined with omeprazole enteric-coated tablets significantly improved gastric mucosal histopathology, reduced inflammatory cytokine levels, enhanced gastric function, and increased the H. pylori eradication rate compared to omeprazole monotherapy.