# Prognostic value of CA15-3, CA125, CEA in breast cancer patients undergoing chemotherapy

## TL;DR

This study shows that exercise interventions during chemotherapy can improve breast cancer patients' exercise knowledge and reduce fatigue and tumor markers.

## Contribution

The novel contribution is demonstrating the effectiveness of planned exercise interventions in reducing tumor marker levels during chemotherapy.

## Key findings

- Exercise intervention improved patients' exercise cognition and reduced cancer-related fatigue.
- The test group showed significantly lower levels of CA15-3, CA125, and CEA compared to the control group.
- Planned behavior-based exercise improved behavioral, sensory, emotional, and cognitive fatigue scores.

## Abstract

To explore the prognostic value of cancer antigen 15-3 (CA15-3), Carbohydrate antigen 125 (CA125), and carcino-embryonic antigen (CEA) in breast cancer patients undergoing chemotherapy.

The data of 100 patients with breast cancer who received chemotherapy in a hospital from May 2022 to May 2024 were selected. Patients were divided into control and test groups based on different intervention methods and hospital stays. The control group receives routine nursing interventions. The test group implements exercise intervention under planned behaviour planning, with 50 cases in each group. Patients' exercise cognitive score, cancer-related fatigue, and serum tumour marker levels are compared before, 2 weeks, and 4 weeks of intervention.

Before the intervention, there was no difference in exercise cognition scores, cancer-related fatigue (CFS) scores, or serum tumour marker levels (P>0.05). After 2 and 4 weeks of intervention, the exercise attitude, exercise values, exercise behaviour control, and exercise motivation in the test group exceeded the control group (P<0.05). The behavioural, sensory, emotional, and cognitive fatigue scores in the test group were below the control group (P<0.05). The CA15-3, CA125, and CEA in the test group were below the control group (P<0.05).

Exercise intervention under planned behaviour planning is conducive to improving the cognition of breast cancer chemotherapy patients on exercise knowledge, alleviating body fatigue, and reducing the serum markers.