# Efficacy and Tolerability of a Topical Peptide‐Hyaluronic Acid Lip Treatment Using a Novel Delivery System in Subjects With and Without Prior Lip Augmentation

## TL;DR

A new topical treatment using hyaluronic acid significantly improves lip appearance and is well-tolerated in both untreated and previously-augmented lips.

## Contribution

A novel delivery system for hyaluronic acid provides effective noninvasive lip treatment with proven aesthetic improvements.

## Key findings

- RLF-TRV significantly improved shine, texture, and vermilion border in both studies.
- High participant satisfaction was reported with 94% and 88% showing improvement in the two studies.
- No adverse events were recorded, indicating good tolerability of the treatment.

## Abstract

Lips are prone to dehydration and aging. Effective noninvasive hyaluronic acid (HA) delivery remains challenging.

To evaluate topical Replenishing Lip Filler‐Tiered Release Vesicles (RLF‐TRV) in filler‐naïve and previously‐augmented lips.

Two single‐center trials evaluated efficacy and tolerability of RLF‐TRV Serum. Study 1 included filler‐naïve subjects or those without lip filler for 12 months. Study 2 enrolled subjects with prior HA lip augmentation (3–9 months earlier) in a double‐blind, placebo‐controlled design. Participants applied RLF‐TRV or placebo twice daily for 3 weeks, followed by a 2‐week regression period. Outcomes included grading of shine, texture, and vermilion border, Investigator and Subject Global Aesthetic Improvement Scale (I‐GAIS, S‐GAIS), and satisfaction. Imaging and tolerability assessments were conducted throughout the study.

RLF‐TRV significantly improved lip aesthetics (shine, texture, and vermilion border), with high satisfaction across both studies. In Study 1, 94% of treated participants were “Improved” on I‐GAIS (p < 0.001), and 81% were “Much‐Improved” on S‐GAIS (p < 0.05). In Study 2, 88% of treated participants were “Improved” on both I‐GAIS and S‐GAIS. RLF‐TRV was well tolerated, with no recorded adverse events.

RLF‐TRV significantly improved lip aesthetics, offering a noninvasive alternative or complementary treatment to injectable procedures.