# A Case of Refractory Mycoplasma Pneumonia With Extra-pulmonary Manifestations in a Community-Acquired Setting

**Authors:** Shweta S Acharya, Burabattula B Shashank, Ashok Kumar, Pankhuri Kumari, Ashok Kumar

PMC · DOI: 10.7759/cureus.95193 · Cureus · 2025-10-22

## TL;DR

A young woman with Mycoplasma pneumonia experienced severe symptoms and autoimmune complications, highlighting the need for early detection and treatment.

## Contribution

Demonstrates a rare case of Mycoplasma pneumonia with autoimmune complications in a community-acquired setting.

## Key findings

- Mycoplasma pneumonia can lead to systemic immune activation and autoimmune hemolytic anemia.
- Prompt treatment with antimicrobials and steroids improved clinical outcomes.
- Early recognition of atypical pathogens is crucial for effective management.

## Abstract

This case highlights a young female in her early twenties who presented with fever and persistent dry cough of one week duration. After ruling out other conditions she was subsequently diagnosed as Mycoplasma pneumonia. It is one of the important causes of atypical pneumonia. The manifestations can range from mild upper respiratory tract infections to severe pulmonary and extra-pulmonary manifestations. The patient's clinical course was complicated by systemic immune activation, which manifested as elevated inflammatory markers, radiological and clinical worsening and development of autoimmune hemolytic anemia. Prompt identification and management with appropriate antimicrobials and other supportive therapy along with timely use of steroid led to steady clinical improvement. This case underlines the importance of considering atypical pathogens in febrile respiratory illnesses and the vigilance for early recognition of systemic immune phase complications.

## Linked entities

- **Diseases:** autoimmune hemolytic anemia (MONDO:0020108)

## Full-text entities

- **Diseases:** pneumonia (MESH:D011014), dry cough (MESH:D003371), autoimmune hemolytic anemia (MESH:D000744), respiratory tract infections (MESH:D012141), fever (MESH:D005334), febrile respiratory illnesses (MESH:D012131), Mycoplasma Pneumonia (MESH:D011019), inflammatory (MESH:D007249)
- **Chemicals:** steroid (MESH:D013256)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12638272/full.md

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12638272/full.md

## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC12638272/full.md

---
Source: https://tomesphere.com/paper/PMC12638272