# Treatment of Recurrent IgA Nephropathy After Kidney Transplantation: Case Report and Comprehensive Literature Review

**Authors:** Ahmad Matarneh, Omar Salameh, Monika Koirala, Amanda Karasinski, Gurwant Kaur, Naman Trivedi, Nasrollah Ghahramani, Vaqar Shah

PMC · DOI: 10.1002/ccr3.71474 · Clinical Case Reports · 2025-11-21

## TL;DR

This paper reports a successful treatment of recurring IgA nephropathy in a kidney transplant patient using a new drug combination.

## Contribution

The study demonstrates the effectiveness of combining targeted-release budesonide with sparsentan in managing recurrent IgA nephropathy post-transplant.

## Key findings

- Targeted-release budesonide combined with sparsentan successfully managed recurrent IgA nephropathy in a kidney transplant patient.
- Early recognition and treatment are crucial for preserving long-term allograft function in such cases.

## Abstract

Recurrent IgA nephropathy after kidney transplantation remains a major cause of graft dysfunction. This case highlights successful management with targeted‐release budesonide combined with sparsentan, underscoring the importance of early recognition and the promise of emerging therapies to preserve long‐term allograft function.

## Linked entities

- **Chemicals:** budesonide (PubChem CID 5281004), sparsentan (PubChem CID 10257882)
- **Diseases:** IgA nephropathy (MONDO:0005342)

## Full-text entities

- **Diseases:** IgA Nephropathy (MESH:D005922)
- **Chemicals:** budesonide (MESH:D019819), sparsentan (MESH:C000634424)

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12638209/full.md

## References

25 references — full list in the complete paper: https://tomesphere.com/paper/PMC12638209/full.md

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Source: https://tomesphere.com/paper/PMC12638209