# Hepatic Peliosis due to Azathioprine in a Pediatric Kidney Transplant Recipient

**Authors:** Antoine Mouche, Cyrielle Parmentier, Marion Almes, Charlotte Mussini, Tim Ulinski, Jean-Daniel Delbet

PMC · DOI: 10.1155/crhe/8752052 · Case Reports in Hepatology · 2025-11-14

## TL;DR

A 5-year-old girl developed liver damage from azathioprine, an immunosuppressant used after a kidney transplant.

## Contribution

This case highlights azathioprine's rare but serious side effect of hepatic peliosis in pediatric transplant patients.

## Key findings

- Hepatic peliosis occurred in a child 9 months after kidney transplant while on azathioprine.
- Azathioprine is a known immunosuppressant but its rare liver toxicity is under-recognized in pediatric cases.

## Abstract

Azathioprine, an antimetabolite drug interfering with purines synthesis, is one of the immunosuppressive maintenance therapy used in solid organ transplant or dysimmune disease. We report the case of a 5-year-old-girl with Stage 5 chronic kidney disease, who developed hepatic peliosis due to azathioprine used 9 months after kidney transplant.

## Linked entities

- **Chemicals:** azathioprine (PubChem CID 2265)
- **Diseases:** hepatic peliosis (MONDO:0004717)
- **Species:** Homo sapiens (taxon 9606)

## Full-text entities

- **Diseases:** dysimmune disease (MESH:D004194), Hepatic Peliosis (MESH:D016917), chronic kidney disease (MESH:D051436)
- **Chemicals:** purines (MESH:D011687), Azathioprine (MESH:D001379)

## Full text

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## Figures

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## References

14 references — full list in the complete paper: https://tomesphere.com/paper/PMC12638160/full.md

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Source: https://tomesphere.com/paper/PMC12638160