# GBA Solver: a user-friendly web server for growth balance analysis

## TL;DR

GBA Solver is a web tool that simplifies the creation and analysis of growth balance models for cell metabolism.

## Contribution

The novel contribution is a user-friendly, no-coding web interface for GBA modeling, integrating enzyme data and visualization tools.

## Key findings

- GBA Solver allows models with up to 20 reactions and uses BRENDA database parameters.
- The platform provides interactive visualizations and lowers technical barriers for GBA modeling.
- It expands access to computational tools for studying cell metabolism and growth.

## Abstract

GBA Solver is a web-based application that enables efficient construction and numerical solution of coarse-grained growth balance analysis (GBA) models containing up to 20 reactions. The platform features an intuitive spreadsheet-based interface that eliminates the need for programming, integrates kinetic parameters from the BRENDA enzyme database, and provides interactive visualizations for model exploration. By lowering technical barriers, GBA Solver makes GBA modeling accessible to a wider scientific community, expanding the computational toolkit for investigating cell metabolism and growth.

GBA Solver is freely available at: https://cellgrowthsim.com/. The source code is available at: https://doi.org/10.5281/zenodo.17250925.