# Multi-omics analysis indicates an association between TAPBP and prostate cancer

## TL;DR

This study identifies TAPBP as a gene strongly associated with prostate cancer through multi-omics analysis.

## Contribution

The study introduces TAPBP as a novel gene strongly linked to prostate cancer using integrated multi-omics approaches.

## Key findings

- Eight genes were found to have protein abundance associated with prostate cancer.
- TAPBP was identified as the most strongly associated gene through combined single-cell and MR analyses.
- Four of the eight genes were validated at the transcriptome level.

## Abstract

Prostate cancer is one of the most common malignant tumors among men worldwide, and surgery remains its mainstay of treatment. It is unclear how prostate cancer develops and what the most effective drug targets are for treating prostate cancer. Therefore, we sought to identify the genes responsible for prostate cancer. By integrating multidimensional and high-throughput data, proteome wide association studies (PWAS), transcriptome wide association studies (TWAS), single-cell sequencing, functional enrichment, Mendelian randomization (MR), and Bayesian co-localization analyses were used to screen for candidate genes that may contribute to prostate cancer and associate with clinical results of prostate cancer. Our comprehensive analysis showed that protein abundance of eight genes was associated with prostate cancer, four of which were validated at the transcriptome level. These 8 candidate genes (MSMB, PLG, CHMP2B, ATF6B, EGF, TAPBP, GAS1 and MMP7) were validated. After combining single-cell sequencing, Mendelian randomization, and Bayesian co-localization analyses, we identified 1 gene (TAPBP) that is strongly associated with prostate cancer.