# Editorial: Heme physiology and pathology

**Authors:** Elena Di Pierro, Tiago L. Duarte

PMC · DOI: 10.3389/fphys.2025.1731803 · Frontiers in Physiology · 2025-11-07

## Full-text entities

- **Genes:** HP (haptoglobin) [NCBI Gene 3240] {aka HP2ALPHA2, HPA1S}, LRP1 (LDL receptor related protein 1) [NCBI Gene 4035] {aka A2MR, APOER, APR, CD91, DDH3, IGFBP-3R}, Nt5e (5' nucleotidase, ecto) [NCBI Gene 58813] {aka CD73, Nt5}, TFR2 (transferrin receptor 2) [NCBI Gene 7036] {aka HFE3, TFRC2}, Mbtps1 (membrane-bound transcription factor peptidase, site 1) [NCBI Gene 89842] {aka S1p, Ski-1}, TLR4 (toll like receptor 4) [NCBI Gene 7099] {aka ARMD10, CD284, TLR-4, TOLL}, HMOX1 (heme oxygenase 1) [NCBI Gene 3162] {aka HMOX1D, HO-1, HSP32, bK286B10}, RAB5A (RAB5A, member RAS oncogene family) [NCBI Gene 5868] {aka RAB5}, TF (transferrin) [NCBI Gene 7018] {aka HEL-S-71p, PRO1557, PRO2086, TFQTL1}, TFRC (transferrin receptor) [NCBI Gene 7037] {aka CD71, IMD46, T9, TFR, TFR1, TR}, HPX (hemopexin) [NCBI Gene 3263] {aka HX}, ALAS1 (5'-aminolevulinate synthase 1) [NCBI Gene 211] {aka ALAS, ALAS-H, ALAS3, ALASH, MIG4}
- **Diseases:** Polycythemia (MESH:D011086), Priapism (MESH:D011317), Thalassemia (MESH:D013789), red cell and systemic disorders (MESH:C562718), Chronic hemolysis (MESH:D006461), hypoxemia (MESH:D000860), ARDS (MESH:D012128), Liver Disease (MESH:D008107), inflammation (MESH:D007249), iron overload (MESH:D019190), hemoglobinopathy (MESH:D006453), non-alcoholic fatty liver disease (MESH:D065626), Sickle Cell Disease (MESH:D000755), liver injury (MESH:D017093), TD (MESH:D004409), Heme (Dys) (MESH:D046351), porphyrias (MESH:D011164), hepatocellular carcinoma (MESH:D006528), vaso-occlusion (MESH:D001157), toxicity (MESH:D064420), acute liver failure (MESH:D017114), COVID (MESH:D000086382)
- **Chemicals:** iron (MESH:D007501), nitric-oxide (MESH:D009569), oxygen (MESH:D010100), cyclic guanosine monophosphate (MESH:D006152), adenosine (MESH:D000241), steroids (MESH:D013256), 2,3-BPG (-), butyrate (MESH:D002087), Heme (MESH:D006418)
- **Species:** Homo sapiens (human, species) [taxon 9606], Rattus norvegicus (brown rat, species) [taxon 10116]
- **Cell lines:** HL-60 — Homo sapiens (Human), Adult acute myeloid leukemia with maturation, Cancer cell line (CVCL_0002)

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12635847/full.md

---
Source: https://tomesphere.com/paper/PMC12635847