# Multiple relapses of mantle cell lymphoma as different extranodal lesions: A case report

## TL;DR

This case report describes a rare instance of mantle cell lymphoma relapsing in unusual extranodal locations, highlighting the need for clinicians to monitor these sites.

## Contribution

The novelty lies in documenting multiple relapses of MCL in rare extranodal sites such as the ocular adnexa, soft tissue, and heart.

## Key findings

- MCL relapsed in the patient's ocular adnexa, soft tissue, and heart—uncommon extranodal sites.
- The case emphasizes the importance of monitoring rare extranodal locations for MCL recurrence.
- Clinicians should be aware of the diverse extranodal manifestations of MCL for accurate diagnosis and treatment.

## Abstract

Mantle cell lymphoma (MCL) usually affects the lymph nodes; however, extranodal involvement is also common, particularly in Waldeyer's ring and the gastrointestinal tract, spleen and bone marrow. Other organs that may be affected include the skin, endocrine glands, lungs and central nervous system, with these sites most commonly affected by relapsing disease. However, in rare, extranodal MCL has arisen in the ocular adnexa, soft tissue and heart. The present study reports the case of a 75-year-old male patient, who experienced repeated relapses of MCL, involving ocular adnexa, soft-tissue and cardiac lesions, which are rare. The aim of the present case report was to demonstrate that clinicians should be aware of the various extranodal sites at which MCL can arise, and monitor patients carefully during and after treatment.