# Associations among vegetation cover, particulate matter, and cardiovascular health in urban environments: a path analysis

**Authors:** Chengkang Wang, Xuyang Sun, Yuchong Wang, Zherui Bai, Lina Kang, Biao Xu, Jun Jin, Jiajie Cao, Yajing Mao, Xuan Wei, Huilin Liang

PMC · DOI: 10.3389/fpls.2025.1659005 · Frontiers in Plant Science · 2025-11-07

## TL;DR

This study shows how urban green spaces improve cardiovascular health by reducing air pollution and improving metabolic markers.

## Contribution

The novel contribution is identifying PM10 as a key intermediary in the vegetation-health pathway and highlighting Leaf Area Index as a critical vegetation metric.

## Key findings

- Higher vegetation cover is linked to lower PM10 levels, which in turn improves metabolic profiles.
- Lower blood glucose is strongly associated with reduced heart failure incidence.
- Leaf Area Index shows the strongest association with cardiovascular health outcomes.

## Abstract

Understanding the complex associative pathways linking urban green spaces to resident health is crucial for sustainable urban development and public health.

This study aimed to investigate the indirect associations between residential vegetation cover (VC) and cardiovascular health, exploring the sequential roles of particulate matter (PM) and key physiological biomarkers in a large patient cohort. Using partial least squares structural equation modeling on 32,667 patient records from Nanjing, China, we constructed a series of path models to analyze these relationships.

Our findings reveal a significant indirect association between residential VC and cardiovascular health outcomes. Specifically, our path analysis reveals that higher VC is linked to lower concentrations of PM, with PM10 (particles ≤10mm) emerging as the dominant intermediary over PM2.5. In turn, lower PM10 levels are associated with healthier metabolic profiles—particularly lower total cholesterol and blood glucose levels —which were subsequently linked to better cardiovascular outcomes. Notably, total cholesterol was a key factor for reduced hospitalization frequency, while blood glucose was more strongly associated with lower incidence of heart failure. Among various vegetation metrics, Leaf Area Index demonstrated the strongest association within these pathways.

Our analysis provides evidence for a specific environmental health pathway (Vegetation → PM10 → Metabolic Biomarkers → Cardiovascular Outcomes) and highlights that vegetation quality, particularly Leaf Area Index, is a key factor. These findings offer valuable insights for urban planners and public health officials aiming to design healthier cities by leveraging the air-purifying benefits of urban green spaces.

## Linked entities

- **Diseases:** heart failure (MONDO:0005252)

## Full-text entities

- **Diseases:** heart failure (MESH:D006333)
- **Chemicals:** blood glucose (MESH:D001786), cholesterol (MESH:D002784), PM10 (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12634656/full.md

## References

59 references — full list in the complete paper: https://tomesphere.com/paper/PMC12634656/full.md

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Source: https://tomesphere.com/paper/PMC12634656