# Anlotinib added to third generation EGFR tyrosine kinase inhibitor therapy for advanced NSCLC patients with oligo-progression: a retrospective study (ALTER-L058)

## TL;DR

Adding anlotinib to EGFR TKI therapy improved progression-free survival in NSCLC patients with oligo-progression, according to a retrospective study.

## Contribution

Demonstrates that anlotinib added to EGFR TKI therapy significantly improves progression-free survival in oligoprogressive NSCLC patients.

## Key findings

- Median progression-free survival was 9.23 months with anlotinib plus EGFR TKI versus 5.42 months with EGFR TKI alone.
- Anlotinib was well tolerated with manageable adverse events in the study population.
- The hazard ratio for progression or death was 0.38, indicating a significant benefit from adding anlotinib.

## Abstract

To investigate the efficacy of anlotinib, an antiangiogenic multikinase inhibitor, as an add-on therapy to first-line epidermal growth factor receptor (EGFR) tyrosine-kinase inhibitor (TKI) for patients with EGFR-mutant non-small cell lung cancer (NSCLC) who were previously untreated before first-line EGFR TKI but subsequently developed oligoprogression.

This multicenter, retrospective cohort study (ALTER-L058) analyzed data from the electronic health records-derived de-identified systems at 16 cancer centers in China. Adult patients between 18 and 75 years of age with histologically or cytologically confirmed locally advanced or metastatic NSCLC who received first-line third-generation EGFR TKI monotherapy and had an oligoprogressive disease were included. Eligible patients received anlotinib (8, 10 or 12 mg) on days 1–14 of each 3-week cycle for ≥6 cycles. Tumor response was assessed radiologically by investigators per RECIST, version 1.1. The primary outcome was investigators-assessed progression-free survival, calculated from the date of medication initiation for the oligoprogressive disease to the first documented progressive disease or death.

Between January 2020 and December 2023, 100 patients received EGFR TKI plus anlotinib and 50 received EGFR TKI. At the data cutoff (20 November 2024), the median progression-free survival was 9.23 months (95% CI, 8.94–10.87) with EGFR TKI plus anlotinib versus 5.42 months (95% CI, 4.83–6.80) with EGFR TKI (hazard ratio [HR] = 0.38, 95% CI, 0.26–0.56; log rank test, P < 0.0001), meeting the primary endpoint. Anlotinib was generally well tolerated, with manageable adverse events.

Anlotinib, when added onto EGFR TKI therapy following gradual progression or oligo-progression, conferred significant PFS benefits upon EGFR mutant NSCLC patients, supporting adding anlotinib to ongoing first-line EGFR TKI therapy for oligoprogressive disease.