# Primary Central Nervous System (CNS) Post-Transplant Lymphoproliferative Disorder: A Case Report

## TL;DR

A rare case of brain lymphoma occurring 15 years after a kidney transplant highlights the need for ongoing monitoring in transplant patients.

## Contribution

This case report documents a rare instance of primary central nervous system PTLD occurring long after transplantation.

## Key findings

- PTLD can manifest as a primary central nervous system disorder even 15 years post-transplantation.
- The case emphasizes the importance of vigilance in post-transplant care for non-dermatologic malignancies.

## Abstract

Post-transplant lymphoproliferative disorder (PTLD) is the most common non-dermatologic malignancy in patients with a history of solid organ transplantation (SOT). The onset of PTLD is not limited to a specific timeframe post-SOT, but most cases are diagnosed within five years of transplantation. While both metastatic spread and multifocal involvement are common, very few of these cases arise from the central nervous system. Here, we present a patient with progressive memory loss 15 years after renal transplantation who was found to have primary central nervous system PTLD. This case underscores the importance of continued vigilance in post-transplantation care.