# Prolonged Gastric Retention of Sodium Zirconium Cyclosilicate: A Case Report

**Authors:** Masafumi Yoshinaga, Hiroshi Adachi, Kwonil Choi, Motohiro Shimizu

PMC · DOI: 10.7759/cureus.95106 · Cureus · 2025-10-21

## TL;DR

A 72-year-old man experienced prolonged retention of a medication in his stomach, highlighting a potential risk and the need for monitoring.

## Contribution

This case report documents an unusual instance of SZC retention in the stomach without prior gastrointestinal issues.

## Key findings

- Radiopaque material from SZC was retained in the stomach for 11 days.
- Gastroscopy confirmed SZC adhered to the gastric wall and was removed via irrigation.

## Abstract

This is a unique case of prolonged gastric retention of sodium zirconium cyclosilicate (SZC) in a 72-year-old man with multiple comorbidities, including acute kidney injury. Although SZC's radiopacity is a known finding, this patient had no apparent GI motility issues. Serial chest X-rays revealed radiopaque material in his stomach for 11 days after he received the medication. Gastroscopy confirmed that the radiopacity was caused by SZC adhering to the gastric wall, which was successfully removed by irrigation. Following irrigation, imaging showed improved gastric radiopacity. This case highlights that prolonged gastric retention of SZC can occur, potentially increasing the risk of complications. We recommend monitoring the passage of orally administered SZC with imaging studies to prevent such occurrences.

## Linked entities

- **Chemicals:** sodium zirconium cyclosilicate (PubChem CID 155804812)
- **Diseases:** acute kidney injury (MONDO:0002492)

## Full-text entities

- **Diseases:** acute kidney injury (MESH:D058186), gastric (MESH:D013272), Gastric Retention (MESH:C565114)
- **Chemicals:** SZC (MESH:C000597310)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

15 references — full list in the complete paper: https://tomesphere.com/paper/PMC12634479/full.md

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Source: https://tomesphere.com/paper/PMC12634479