# The Role of Incretins in Obstructive Sleep Apnea “GLP1RAs and GLP1RA/GIPRAs in OSA”

**Authors:** Ana Lucia Fuentes, Gurleen Dhami, Jeremy Pettus, Praveen Akuthota, Atul Malhotra

PMC · DOI: 10.1111/1753-0407.70170 · Journal of Diabetes · 2025-11-20

## TL;DR

This paper explores how GLP-1 and dual GLP-1/GIP receptor agonists affect organ systems related to sleep apnea and metabolic health.

## Contribution

It introduces new insights into the mechanisms of GLP1RAs and GLP1RA/GIPRAs in obstructive sleep apnea.

## Key findings

- GLP1RAs and GLP1RA/GIPRAs show potential benefits for organ systems impacted by obstructive sleep apnea.
- These agonists may improve cardiometabolic health in patients with sleep apnea.
- The mechanisms of action involve multiple physiological pathways relevant to sleep apnea.

## Abstract

Mechanisms of action and effects of GLP‐1 receptor agonists and dual GLP‐1/GIP receptor agonists on multiple organ systems relevant to obstructive sleep apnea and cardiometabolic health.

## Linked entities

- **Diseases:** obstructive sleep apnea (MONDO:0007147)

## Full-text entities

- **Genes:** GLP1R (glucagon like peptide 1 receptor) [NCBI Gene 2740] {aka GLP-1, GLP-1-R, GLP-1R}
- **Diseases:** OSA (MESH:C535586), Obstructive Sleep Apnea (MESH:D020181)

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12634136/full.md

## References

23 references — full list in the complete paper: https://tomesphere.com/paper/PMC12634136/full.md

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Source: https://tomesphere.com/paper/PMC12634136