# Cellular Angiolipoma in the Breast: A Case Report and Literature Review of Its Pathogenesis

## TL;DR

A rare case of cellular angiolipoma in a woman's breast is reported, highlighting its unique features and benign nature.

## Contribution

This paper presents one of the few documented cases of cellular angiolipoma in the breast and contributes to understanding its pathogenesis.

## Key findings

- Cellular angiolipoma in the breast is extremely rare, with fewer than five cases reported.
- The tumor was predominantly cellular with spindle cells and vascular clusters, but showed no signs of malignancy.
- Negative PAS staining and HHV8 immunohistochemistry supported a benign diagnosis.

## Abstract

Angiolipoma is a benign variant of lipoma characterized by vascular proliferation among mature adipocytes, most commonly found on the extremities of young males. Cellular angiolipoma of the breast is extremely rare, with fewer than five cases reported in the English literature. We present a case of cellular angiolipoma in a 72-year-old female, manifesting as a 0.7 × 0.7 × 0.4 cm hyperechoic mass on ultrasound. Histopathological examination revealed a predominantly cellular lesion (~90%) interspersed with mature adipose tissue and abundant fibrin thrombi within small capillaries. The cellular component comprised spindle cells and vascular clusters with bland nuclei and low mitotic activity. Periodic acid-Schiff (PAS) staining and human herpesvirus 8 (HHV8) immunohistochemistry were negative. A diagnosis of benign cellular angiolipoma of the breast was made, with the tumor superficially involving the subcutaneous layer. The patient recovered uneventfully post-procedure. This report also discusses the pathophysiology and possible mechanisms underlying the development of angiolipoma.