# A qualitative study exploring motivations for participating in research among women who use opioids

**Authors:** Sarah M. Bagley, Ariel D. Maschke, Miriam T. H. Harris, Alexander Y. Walley, Samantha Johnson, Emily Hurstak, John Farley, Sarah G. Keller, Vanessa M. McMahan, Cynthia Barrett, Phillip O. Coffin, Christine M. Gunn, Ali Ahmed, Ali Ahmed, Ali Ahmed

PMC · DOI: 10.1371/journal.pone.0336061 · PLOS One · 2025-11-20

## TL;DR

The study explores why women who use opioids participate in research and finds that trust, compensation, and supportive environments are key factors.

## Contribution

The study identifies novel recruitment strategies and motivational factors specific to women who use opioids in research settings.

## Key findings

- Women showed highest trust when recruited through community organizations and lowest through social media.
- Monetary compensation increased the likelihood of research participation.
- Supportive and destigmatized research environments encouraged participation.

## Abstract

We assessed the acceptability of four recruitment strategies and explored facilitators and barriers to research engagement among women who use opioids.

We recruited self-identified women reporting past 14-day non-prescribed opioid use using four recruitment approaches: community outreach in collaboration with community-partners; snowball sampling; social media campaigns; and passive recruitment through distribution of print materials at community programs. We collected participant demographics, type of recruitment, and substance use via an interview-administered survey. Qualitative interviews explored women’s research experiences, and facilitators and barriers to research engagement. Analysis employed a combination of inductive and deductive approaches to identify themes relevant to women’s engagement in research.

Of 36 enrolled participants, median age was 49 years, 16% were Black, 58% were white, 14% were Hispanic, and 58% had their own house or apartment. We recruited 12 women through community outreach, two through snowball sampling, three through social media, and 19 through print materials. Interviews identified four themes: (1) highest trust when recruited through community organizations and lowest trust when recruited through social media; (2) desire to improve the lives of other women who use drugs drove motivation to participate in research, (3) preference for monetary compensation, which increased the likelihood of in research participation; and (4) women participated when research environments were supportive and destigmatized.

To recruit women who use drugs, researchers should collaborate with trusted community organizations, promote the benefits of research to other women, monetarily and fairly compensate participants, and foster supportive destigmatized environments.

## Full-text entities

- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12633877/full.md

## References

30 references — full list in the complete paper: https://tomesphere.com/paper/PMC12633877/full.md

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Source: https://tomesphere.com/paper/PMC12633877