Editorial Note: Global Regulator SATB1 Recruits β-Catenin and Regulates TH2 Differentiation in Wnt-Dependent Manner

Abstract

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Following the publication of the Expression of Concern on this article [1,2], concerns were raised about regions of similarity within the first two lanes in the left panel of Fig S2A of [1], and that [1] states that “thymocyte viability was not significantly reduced even without using the OP9-DL1 co-culture system (Figure S5A)” without viability percentages or statistical test results in the text or figure legend.

As noted in [2], the images provided in S1 File in [2] to support the left western blot panel of Figure S2A in [1] do not appear to match the published figure panel and did not clarify the concerns about discontinuities or similarities in the published figure. The published figure has a stronger and clearer interaction signal than the underlying images; however, the underlying images – while different from the published figure – show a band in the position that would indicate an interaction, and support the conclusion.

The corresponding author responded to state the following:

The PLOS Biology Editors issue this Editorial Note to provide an update to the Expression of Concern [2] previously issued on this article [1] and to provide readers with the additional information provided about Figure S5.