# O’nyong’nyong Virus Infections in Nigeria: A Case Series

**Authors:** Cyril Erameh, Vivian Kwaghe, Ephraim Ogbaini-Emovon, Jay Osi Samuels, Osahogie Isaac Edeawe, Nankpah Godsave Vongdip, Onyia Justus Ejike, Blessed Okhiria, Ikponmwosa Odia, Jacqueline Agbukor, Lauren P Courtney, Adamu Zigwai Ephraim, Claire A Quiner, Jean H Kim, Philippe Chebu, Oladimeji Damilare Matthew, Victoria Orok, Walter Mary Odion, Blessing Amierhobhiye Obagho, Richard Fayomade, Reuben Eifediyi, Emmanuel A Oga

PMC · DOI: 10.1093/cid/ciaf511 · 2025-11-20

## TL;DR

This paper reports seven cases of o’nyong’nyong virus in Nigeria, showing symptoms similar to malaria and Lassa fever.

## Contribution

The study highlights the importance of improved diagnostics for emerging viral infections in endemic regions.

## Key findings

- Seven patients presented with acute febrile illness caused by o’nyong’nyong virus.
- Clinical symptoms were similar to malaria and Lassa fever, leading to diagnostic challenges.
- The findings emphasize the need for expanded arboviral surveillance in Nigeria.

## Abstract

We report seven patients with detected o’nyong’nong virus infection, presenting with acute febrile illness at two tertiary hospitals in Nigeria. The clinical presentation mimicked malaria and Lassa fever, highlighting the need for expanded arboviral surveillance and diagnostics to distinguish emerging viral infections in endemic settings.

## Linked entities

- **Diseases:** malaria (MONDO:0005136), Lassa fever (MONDO:0005820)

## Full-text entities

- **Diseases:** febrile illness (MESH:D005334), Lassa fever (MESH:D007835), malaria (MESH:D008288), viral infections (MESH:D014777), O'nyong'nyong Virus Infections (MESH:D018354)
- **Species:** Homo sapiens (human, species) [taxon 9606]

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Source: https://tomesphere.com/paper/PMC12631775