# Fulminant Yersinia Pestis Infection in a Known HIV-Positive Patient: A Case Report of Identification in Nigeria 2024

**Authors:** Vivian Gga Kwaghe, Cyril Erameh, Nankpah Godsave Vongdip, Osahogie Isaac Edeawe, Onyia Justus Ejike, Blessed Okhiria, Lauren P Courtney, Claire A Quiner, Jean H Kim, Adamu Zigwai Ephraim, Jay Osi Samuels, Philippe Chebu, Oladimeji Damilare Matthew, Victoria Orok, Ikponmwosa Odia, Jacqueline Agbukor, Femi Owolagba, Ephraim Ogbaini-Emovon, Walter Mary Odion, Blessing Amierhobhiye Obagho, Richard Fayomade, Emmanuel A Oga

PMC · DOI: 10.1093/cid/ciaf512 · 2025-11-20

## TL;DR

A fatal case of Yersinia pestis infection in an HIV-positive patient was reported in Nigeria, highlighting the disease's potential severity and the need for vigilance even in non-endemic regions.

## Contribution

This is the first recent report of Y. pestis infection in Nigeria and emphasizes the risk in immunocompromised individuals.

## Key findings

- A fatal Y. pestis infection was identified in an HIV-positive patient in Nigeria.
- The case highlights the importance of clinical suspicion for plague in non-endemic regions.
- Co-infection in immunocompromised individuals can lead to severe outcomes.

## Abstract

Yersinia pestis is one of the most dangerous pathogens in the world. While plague foci exist in Africa, no recent cases have been reported in Nigeria. We describe a fatal case of Y. pestis infection in a known HIV-positive patient who presented to a tertiary health facility in Nigeria. This case underscores the need for high clinical suspicion, even in regions considered non-endemic, and highlights the potential severity of co-infection in immunocompromised individuals.

## Linked entities

- **Diseases:** plague (MONDO:0019095)
- **Species:** Yersinia pestis (taxon 632)

## Full-text entities

- **Diseases:** co-infection (MESH:D060085), Yersinia Pestis Infection (MESH:D010930)
- **Species:** Yersinia pestis (species) [taxon 632], Homo sapiens (human, species) [taxon 9606], Human immunodeficiency virus 1 (no rank) [taxon 11676]

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Source: https://tomesphere.com/paper/PMC12631769