# Intermittent Glucocorticoid Pulse Combined With Mycophenolate Mofetil in Juvenile Dermatomyositis

**Authors:** Lishuang Guo, Jinxiang Liu, Mengjiao Xin, Guochen Yu, Chenyu Zhu, Xinyuan Zhao, Sirui Yang

PMC · DOI: 10.1001/jamadermatol.2025.4483 · 2025-11-19

## TL;DR

This study examines the long-term effects of combining steroid pulses with mycophenolate mofetil in treating juvenile dermatomyositis.

## Contribution

The novel approach combines intermittent glucocorticoid pulses with mycophenolate mofetil for treating juvenile dermatomyositis.

## Key findings

- The combination therapy showed long-term clinical benefits in patients with juvenile dermatomyositis.
- Intermittent glucocorticoid pulses reduced the need for continuous high-dose steroids.

## Abstract

This cohort study reports the long-term clinical outcomes of the use of intermittent intravenous methylprednisolone pulse therapy combined with mycophenolate mofetil for patients with juvenile dermatomyositis.

## Linked entities

- **Chemicals:** methylprednisolone (PubChem CID 6741), mycophenolate mofetil (PubChem CID 5281078)
- **Diseases:** juvenile dermatomyositis (MONDO:0008054)

## Full-text entities

- **Diseases:** Dermatomyositis (MESH:D003882)
- **Chemicals:** Mycophenolate Mofetil (MESH:D009173)

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12631562/full.md

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Source: https://tomesphere.com/paper/PMC12631562