# Commentary: Iridoids derived from Valeriana jatamansi jones alleviates neuroinflammation and blood spinal cord barrier permeability after spinal cord injury by activating the Nrf2/HO-1 signaling pathway

**Authors:** Kai Zhang, Lei Wu

PMC · DOI: 10.3389/fphar.2025.1699044 · 2025-11-06

## Full-text entities

- **Genes:** HMOX1 (heme oxygenase 1) [NCBI Gene 3162] {aka HMOX1D, HO-1, HSP32, bK286B10}, NFE2L2 (NFE2 like bZIP transcription factor 2) [NCBI Gene 4780] {aka IMDDHH, NRF2, Nrf-2}
- **Diseases:** neuroinflammation (MESH:D000090862), spinal cord injury (MESH:D013119)
- **Chemicals:** Iridoids (MESH:D039823)
- **Species:** Valeriana jatamansi (species) [taxon 59170]

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Source: https://tomesphere.com/paper/PMC12631343