MoG+3.0: expanded structural variant visualization and integration of genomic data from five newly analyzed mouse strains

TL;DR

MoG+3.0 is an updated mouse genome database that includes new data on genetic variations from five mouse strains, helping researchers study diseases and traits in mice.

Contribution

The paper introduces MoG+3.0, which adds structural variant visualization and new genomic data from five mouse strains.

Findings

MoG+3.0 includes SNP, indel, and structural variant data from five new mouse strains.

The database now allows visual examination of structural variants that were previously hard to detect.

The updated database is expected to improve research on mouse disease models and phenotypes.

Abstract

The MoG+ (Mouse Genome database with high added value), which has been operational since 2019, provides detailed visualization of genomic variations in mouse experimental strains, including wild-derived inbred strains, in particular those maintained at RIKEN BioResource Research Center. Here, we report on the enhancement of MoG+ by inclusion of the latest genome reports and by incorporation of structural variation (SV) information from recent analyses. The latter included long-read sequencing studies of the disease model strains FLS/Shi, NC/Nga, STR/OrtCrlj, JF1/Ms, and MSM/Ms. These studies described SNPs (4,482,628 to 19,644,769), short indels (726,646 to 2,391,782), and SVs such as insertions (32,949 to 131,311), deletions (28,259 to 102,226), and inversions (32 to 164). The new version of the database, which is named MoG+3.0, includes a feature that allows users to visually observe variants in the five strains. Through enhancement of the functionality of the database, SVs have been incorporated and visualized, allowing users to visually examine variants that were difficult to detect using only short-read-based resequencing data. The inclusion of the new variant data, along with enhanced features such as visualization, is expected to serve as a valuable resource for studies of disease and phenotype in experimental mice.

The online version contains supplementary material available at 10.1007/s00335-025-10168-2.

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