Movement disorders: a brief overview from an evolutionary perspective
Pedro J. Garcia Ruiz
TL;DR
This paper explores movement disorders like Parkinson's and Huntington's through an evolutionary lens, examining how evolutionary trade-offs may influence these diseases.
Contribution
The paper introduces an evolutionary perspective to understand the origins and progression of movement disorders.
Findings
Evolutionary bottlenecks may contribute to neurodegenerative disease mechanisms.
Genetic alleles may reflect evolutionary trade-offs between early-life benefits and late-life risks.
Antagonistic pleiotropy theory is applied to explain movement disorders like Parkinson’s and Huntington’s.
Abstract
Evolutionary approach tries to explain several aspects of neurological diseases under the perspective of evolution. Evolutive bottle-neck may explain some aspects of neurodegenerative diseases. Additionally, a number of genetic alleles may reflect an evolutionary trade-off between benefits in early life and late-life disadvantages. Antagonistic pleiotropy theory suggests that some adaptive evolutionary changes increase individual fitness early in life, but can exacerbate detrimental aging-related processes We discuss three diseases with movement disorders from an evolutionary perspective: Parkinson’s disease, Huntington’s disease, and Tourette syndrome.
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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Taxonomy
TopicsGenetic Neurodegenerative Diseases · Parkinson's Disease Mechanisms and Treatments · Neurological disorders and treatments