# Clinical Significance of Mesiobuccal and Distobuccal Canal Variations in Maxillary Molars: A Case Series and a Mini Review

**Authors:** Mohsen Aminsobhani, Somayeh Majidi

PMC · DOI: 10.1155/crid/5581317 · 2025-11-12

## TL;DR

This paper discusses the importance of identifying rare canal variations in maxillary molars to improve endodontic treatment success.

## Contribution

The study highlights the clinical relevance of MB3 and DB2 canals through case examples and emphasizes the need for advanced imaging.

## Key findings

- MB3 and DB2 canals are clinically significant but often overlooked in maxillary molars.
- Advanced imaging like CBCT is essential for detecting these canal variations.
- The study encourages further research on the impact of these canals on treatment outcomes.

## Abstract

Endodontic treatment success is contingent upon the comprehensive identification and management of all root canals within a tooth's complex anatomy. This is particularly challenging in maxillary molars, which exhibit significant variability in canal morphology. While the presence of two canals in the mesiobuccal (MB) root is well documented, the occurrence of a third canal (MB3) is less common yet clinically relevant. Additionally, the distobuccal (DB) root, typically containing a single canal, may occasionally harbor a second canal (DB2). This case series presents clinical cases that highlight the prevalence and significance of MB3 and DB2 canals in maxillary molars. The findings underscore the necessity for meticulous canal detection using advanced imaging techniques such as cone beam computed tomography (CBCT), as traditional diagnostic methods may overlook these anatomical variations. By sharing these cases, we aim to enhance awareness and encourage further research into the implications of these additional canals on endodontic treatment outcomes.

## Full-text entities

- **Genes:** RNF130 (ring finger protein 130) [NCBI Gene 55819] {aka G1RP, G1RZFP, GOLIATH, GP}, VEZF1 (vascular endothelial zinc finger 1) [NCBI Gene 7716] {aka CMD1OO, DB1, ZNF161}
- **Diseases:** calcification (MESH:D002114), infection (MESH:D007239), swelling (MESH:D004487), IRM (MESH:D054019), root fractures (MESH:D011843), inflammation (MESH:D007249), abscess (MESH:D000038), complications (MESH:D008107), buccal swelling (MESH:D000080902), MFM (MESH:C563718), hypothyroidism (MESH:D007037), pain (MESH:D010146), periodontal disease (MESH:D010510), erythema (MESH:D004890), apical abscess (MESH:D010482), bleeding (MESH:D006470), periapical disease (MESH:D010483), hypersensitivity (MESH:D004342), tenderness (MESH:D063806), Pulpitis (MESH:D011671)
- **Chemicals:** co-amoxiclav (MESH:D019980), EDTA (MESH:D004492), Ca(OH)2 (MESH:D002126), epinephrine (MESH:D004837), NaOCl (MESH:D012973), eucalyptol (MESH:D000077591), lidocaine (MESH:D008012), MTA (MESH:D000068437), levothyroxine (MESH:D013974), DOM (-), AH-26 (MESH:C028044), P (MESH:D010758), CHX (MESH:D002710), MB3 (MESH:C005543), NiTi (MESH:C040654), water (MESH:D014867), zinc oxide (MESH:D015034)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

16 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12629697/full.md

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Source: https://tomesphere.com/paper/PMC12629697