Quercetagetin From Tagetes erecta Differentially Induces Autophagy and Ferroptosis in MDA-MB-231 and JC Breast Cancer Cells
L. Sánchez-Sánchez, H. López-Muñoz, O. M. Echeverría, N. Torres-Ramírez, J. J. Alvarado-Sansininea, D. Bahena-Salmerón, J. I. Martínez-Flores, N. González, M. L. Escobar
TL;DR
Quercetagetin from Tagetes erecta kills breast cancer cells through different cell death pathways depending on the species, with minimal impact on healthy cells.
Contribution
Quercetagetin induces species-specific programmed cell death in breast cancer cells, offering a novel approach for targeted cancer therapy.
Findings
Quercetagetin shows dose-dependent antiproliferative effects on MDA-MB-231 and JC breast cancer cells.
MDA-MB-231 cells undergo apoptosis and autophagy, while JC cells undergo ferroptosis upon quercetagetin treatment.
Quercetagetin has minimal impact on noncancerous lymphocytic cells.
Abstract
Quercetagetin is a flavonoid that has shown antiproliferative effects against different human cancers. We thoroughly analysed the effects of quercetagetin obtained from Tagetes erecta on human triple-negative breast cancer cells (MDA-MB-231) and murine breast cancer cells (JC) to elucidate its underlying antineoplastic mechanisms. Quercetagetin exerted dose-dependent antiproliferative effects on both cell lines (half-maximal inhibitory concentration: 188 and 282 μM, respectively). While it eliminated MDA-MB-231 cells via both apoptosis and autophagy, it predominantly eliminated JC cells via ferroptosis. Our results demonstrate that quercetagetin induces different programmed cell death pathways in a species-specific manner. Notably, quercetagetin did not significantly affect the proliferation of noncancerous lymphocytic cells. These data may facilitate the development of anticancer drugs…
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Taxonomy
TopicsFerroptosis and cancer prognosis · Cancer, Stress, Anesthesia, and Immune Response · Cancer, Lipids, and Metabolism