# Pleomorphic Adenoma-Like Tumor in the Kidney: Case Report of a Rare Mixed Tumor

**Authors:** Eric Y. Zhang, Haneen T. Salah, Danice K. Torman, Mukul K. Divatia, Haijun (Steve) Zhou

PMC · DOI: 10.1155/crin/8959506 · 2025-11-12

## TL;DR

This paper reports a rare case of a kidney tumor resembling a pleomorphic adenoma, which typically originates in salivary glands, and highlights its unusual metastatic behavior.

## Contribution

The paper presents the 13th reported case of kidney metastasis from a pleomorphic adenoma and the second without a known primary salivary gland tumor.

## Key findings

- The tumor displayed typical pleomorphic adenoma features like chondromyxoid stroma and benign ductal cells.
- This case contributes to the limited literature on benign mixed tumors resembling metastasizing pleomorphic adenoma in the kidney.
- Patient outcomes were compared to prior studies, emphasizing the rarity and diagnostic challenges of such tumors.

## Abstract

Pleomorphic adenoma is the most common salivary gland tumor and is notably able to metastasize while displaying a benign-appearing morphological appearance, greatly resembling that of the primary tumor.

Here, we report a case of a 66-year-old male who presented with a 7-month history of a left upper renal mass. Microscopic examination revealed characteristics typical of pleomorphic adenoma, including chondromyxoid stroma and benign ductal and tubular cells. Consequently, a diagnosis of benign mixed tumor resembling a metastasizing pleomorphic adenoma (MPA) to the kidney was made.

We report a rare instance of a tumor resembling pleomorphic adenoma with metastasis to the kidney, the 13th reported case of kidney metastasis in the literature. This case is additionally the 2nd case with metastases to the kidney and no known primary salivary gland tumor. We believe that this entity is most consistent with the histopathological findings reported in our case, despite the lack of a patient history of primary salivary gland tumor. We subsequently compare patient outcomes across all known cases of benign MPA to the kidney or PA-like tumors in the kidney with patient outcomes described in a 2015 study that analyzed all cases of MPA in the literature.

## Linked entities

- **Diseases:** pleomorphic adenoma (MONDO:0008401)

## Full-text entities

- **Diseases:** like (MESH:C537419), PA (MESH:C535387), salivary gland tumor (MESH:D012468), kidney metastasis (MESH:D007674), metastases (MESH:D009362), upper renal mass (MESH:C536030), MPA (MESH:D008949), Tumor (MESH:D009369)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12629694/full.md

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Source: https://tomesphere.com/paper/PMC12629694