Prostatic Abscess due to Ureaplasma parvum in a Heart Transplant Recipient: Diagnostic Challenges and Clinical Utility of Metagenomics Next-Generation Sequencing (NGS)

TL;DR

A heart transplant patient developed a rare prostate abscess caused by Ureaplasma parvum, identified using next-generation sequencing.

Contribution

This case highlights the clinical utility of metagenomic NGS in diagnosing rare infections in immunocompromised patients.

Findings

Ureaplasma parvum was identified as the cause of a prostate abscess in a heart transplant recipient.

Next-generation sequencing proved effective in diagnosing rare and fastidious bacterial infections.

The case expands the known clinical manifestations of Ureaplasma spp. in immunocompromised individuals.

Abstract

Ureaplasma spp. are small and fastidious bacteria that may cause urogenital infections in healthy adults and, in rare cases, invasive disease. These bacteria have been increasingly recognized in immunocompromised patients and have been associated with hyperammonemia syndrome, particularly in lung transplant recipients. In this context, we present a unique clinical case of Ureaplasma parvum prostate abscess, a condition rarely observed in heart transplant recipients, diagnosed using next-generation sequencing (NGS).

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