Sustainable green synthesis of zinc oxide nanoparticles utilizing Zingiber officinale peel aqueous extract, characterization, and determination of its anticancer and antimicrobial potential
Omaish S. Alqahtani, Uday M. Muddapur, Keerti Kamat, Aparna Shenvi, Ibrahim Ahmed Shaikh, Ibrahim Aljaezi, Bassam S. M. Al Kazman, Mohammed A. Alshamrani, Aejaz Abdullatif Khan, Awad Mohammed Al-Qahtani, Basheerahmed Abdulaziz Mannasaheb, Layikh Ahmed
TL;DR
This study shows how to make zinc oxide nanoparticles from ginger peel in an eco-friendly way and tests their ability to fight cancer and microbes.
Contribution
The novelty is the green synthesis of ZnONPs using ginger peel and their comprehensive antimicrobial and anticancer evaluation.
Findings
ZnONPs synthesized at 50–60°C and pH 10 showed optimal stability and formation.
ZnONPs exhibited strong antibacterial and antifungal activity against multiple pathogens.
ZnONPs reduced breast cancer cell viability with an IC50 of 82.13 µg/mL.
Abstract
This study demonstrates the green synthesis, characterization, and biomedical applications of zinc oxide nanoparticles (ZnONPs) using Zingiber officinale (Z. officinale) (ginger) peel extract. Green synthesis offers advantages over conventional methods, including environmental friendliness, cost-effectiveness, and enhanced biocompatibility. Ultraviolet-Visible (UV-Vis) spectroscopy confirmed ZnONPs formation with a peak at 364 nm. Fourier-Transform Infrared (FTIR) spectroscopy analysis revealed characteristic peaks indicating functional groups involved in nanoparticle formation. Scanning Electron Microscope (SEM) analysis showed spherical/agglomerated nanoparticles, and Energy-Dispersive X-ray Spectroscopy (EDS) confirmed 77.7% zinc oxide by mass%. The X-ray Diffraction (XRD) indicated an average particle size of 24.67 nm with distinct crystal orientations. Phytochemical analysis…
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Taxonomy
TopicsNanoparticles: synthesis and applications · ZnO doping and properties · Ginger and Zingiberaceae research