# Staphylococcus aureus nasal carriage is associated with faster symptom resolution following nasal allergen challenge in ragweed-allergic participants: a subset of the Allergic Rhinitis Microbiome Study

## TL;DR

Staphylococcus aureus in the nose may help reduce allergy symptoms faster after an allergen challenge in ragweed-allergic individuals.

## Contribution

This study shows that nasal carriage of Staphylococcus aureus is linked to faster symptom resolution in ragweed allergy.

## Key findings

- S. aureus carriers had smaller reductions in nasal airflow at 3 and 5 hours post-challenge.
- Carriers reported lower symptom scores at 48 hours compared to non-carriers.
- No significant difference was observed in the initial response within the first three hours.

## Abstract

In this letter, we report that ragweed-allergic participants with nasal Staphylococcus aureus carriage (n = 7) exhibited significantly smaller reductions in Peak Nasal Inspiratory Flow from baseline at 3 h (P = 0.013) and 5 h (P = 0.008) post–nasal allergen challenge compared to non-carriers (n = 12). There was no significant difference between carriers and non-carriers in the initial response within the first three hours following the challenge (all P > 0.05). Carriers also reported significantly lower Total Nasal Symptom Scores (P = 0.015) and Total Rhinoconjunctivitis Symptom Scores (P = 0.021) at 48 h. These findings suggest that S. aureus carriage does not exacerbate allergic responses and may instead be associated with more rapid symptom resolution.