Physicochemical Design and In Vitro Evaluation of Diterpene Phytol-Loaded Solid Lipid Nanoparticles
Lannya C. S. Tavares-Pessoa, Alaine M. dos Santos-Silva, Anne Emmanuelle C. S. Melo, Bolívar P. G. de Lima Damasceno, Matheus F. Fernandes-Pedrosa, Alianda M. Cornélio, Arnobio Antônio da Silva-Júnior
TL;DR
Researchers developed stable nanoparticles to deliver phytol, a natural compound with health benefits, showing effective encapsulation and controlled release.
Contribution
A new lipid matrix from Platonia insignis was used to create stable, spherical solid lipid nanoparticles for phytol delivery.
Findings
Nanoparticles with sizes under 300 nm showed high encapsulation efficiency (>90%).
The nanoparticles enabled slow release and dose-dependent cytotoxic effects of phytol.
The lipid matrix (TG1) proved effective for creating stable phytol-loaded nanoparticles.
Abstract
Phytol (PHY) is a water immiscible natural diterpene with interesting pharmacologic and antioxidant properties with great potential for application in foods, cosmetics, and pharmaceuticals. In this letter, a natural 1,3-distearyl-2-oleyl glycerol (TG1) extracted from Platonia insignis Mart was explored as a lipid matrix for preparing uniformly sized and stable PHY-loaded solid lipid nanoparticles (SLN). Different tested compositions induced spherical (<300 nm), stable SLN with high encapsulation efficiency (>90%), able to induce slow release and a dose-dependent cytotoxic effect of PHY. These achievements corroborated with a promising nanocarrier for PHY and are able to be tested in different application fields.
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Click any figure to enlarge with its caption.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsAdvancements in Transdermal Drug Delivery · Natural product bioactivities and synthesis · Essential Oils and Antimicrobial Activity