# Pacinian Neurofibroma of Oral Cavity: A Rare Neurogenic Tumor

**Authors:** Sara Amanpour, Reza Malekpour Afshar, Alireza Parastar

PMC · DOI: 10.30476/dentjods.2025.104390.2527 · 2025-12-01

## TL;DR

This paper reports a rare case of Pacinian neurofibroma in the oral cavity, associated with neurofibromatosis type 1.

## Contribution

The study presents a rare intra-oral case of Pacinian neurofibroma linked to neurofibromatosis type 1.

## Key findings

- Pacinian neurofibroma is typically found on hands and feet, not in the oral cavity.
- The tumor was associated with neurofibromatosis type 1, which is uncommon for this tumor type.
- The case contributes to understanding the clinical and microscopic features of this rare tumor.

## Abstract

Pacinian neurofibroma is a rare variant of neurofibroma composed of structures resembling pacinian corpuscles at various stages of maturation. It is a rare neurogenic tumor which has been reported predominantly on hands, and feet, where pressure receptors are typically located. It usually presents as a solitary nodule and is not reported in associated with von Recklinghausen’s disease or any other syndrome. The intraoral site is unusual. The purpose of this report is to present a rare case of intra-oral pacinian neurofibroma associated with neurofibromatosis type 1 and to describe its clinical and microscopic features contributing for the best knowledge about this rare entity.

## Linked entities

- **Diseases:** neurofibromatosis type 1 (MONDO:0018975)

## Full-text entities

- **Genes:** NF1 (neurofibromin 1) [NCBI Gene 4763] {aka NFNS, VRNF, WSS}
- **Diseases:** Neurogenic Tumor (MESH:D009369), intra- (MESH:D057072), Pacinian Neurofibroma (MESH:D009455), von Recklinghausen's disease (MESH:D009456)

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12627952/full.md

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Source: https://tomesphere.com/paper/PMC12627952