# Towards global healthy longevity: report from the 1st World Longevity Summit in Kyotango, Japan

**Authors:** Tomoya Kitani, Satoaki Matoba, Yuji Naito, Steve Horvath, Tamotsu Yoshimori, Francis K. L. Chan, Tomoo Matsuda, Stefania Bandini, Hironori Nakagami, Ryuichi Morishita, Yasushi Nakayama, Hitoshi Yaku

PMC · DOI: 10.1038/s41514-025-00279-0 · 2025-11-18

## TL;DR

Experts from the 1st World Longevity Summit in Japan discussed ways to promote healthy aging through lifestyle and community strategies.

## Contribution

The paper introduces four pillars for healthy aging, including Ikigai, based on summit discussions.

## Key findings

- Experts identified four pillars for healthy aging: communication bonds, dietary fiber, physical activity, and Ikigai.
- The summit emphasized the importance of community-based health strategies for promoting longevity.
- Lifestyle medicine and aging biology were highlighted as key areas for advancing healthy longevity.

## Abstract

Aging societies around the world face increasing challenges in promoting healthy longevity. The 1st World Longevity Summit in Kyotango, Japan, convened experts to discuss advances in aging biology, lifestyle medicine, and community-based health strategies. The joint declaration outlined four pillars for healthy aging: bonds with communication, dietary fiber, physical activity, and “Ikigai”, a sense of purpose. This report highlights representative summit discussions and presents key insights on healthy longevity.

## Full-text entities

- **Genes:** MAP1LC3A (microtubule associated protein 1 light chain 3 alpha) [NCBI Gene 84557] {aka ATG8E, LC3, LC3A, MAP1ALC3, MAP1BLC3}, RUBCN (rubicon autophagy regulator) [NCBI Gene 9711] {aka KIAA0226, RUBICON, SCAR15}
- **Diseases:** fatigue (MESH:D005221), obesity (MESH:D009765), infections (MESH:D007239), Down syndrome (MESH:D004314), hypertension (MESH:D006973), allergies (MESH:D004342), long COVID (MESH:D000094024), inflammation (MESH:D007249), autism (MESH:D001321), metabolic disorders (MESH:D008659), maternal gestational diabetes (MESH:D016640), chronic (MESH:D002908), COVID-19 (MESH:D000086382), AGE (OMIM:613784), cognitive decline (MESH:D003072), growth hormone deficiency (MESH:D004393)
- **Chemicals:** exopolysaccharides (-), butyrate (MESH:D002087), vitamin D (MESH:D014807), spermidine (MESH:D013095)
- **Species:** Akkermansia (genus) [taxon 239934], Bacteroides (genus) [taxon 816], Homo sapiens (human, species) [taxon 9606], gut metagenome (species) [taxon 749906], Saccharomyces cerevisiae (baker's yeast, species) [taxon 4932]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12627732/full.md

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Source: https://tomesphere.com/paper/PMC12627732