Design and development of an affordable multi-mode small animal ventilator
Patryk Dzierzawski, Bernd Flamm, Verena Hegele, Sashko Spassov, Christin Wenzel, Stefan Schumann, Sara Lozano-Zahonero
TL;DR
Researchers created an affordable, flexible ventilator for small animals that offers precise control and customizable settings for biomedical experiments.
Contribution
A low-cost, multi-mode ventilator with precise control and customizable ventilation profiles for small animal research.
Findings
The ventilator supports tidal volumes of 1–15 ml and respiratory rates up to 120 breaths per minute.
It offers customizable inspiration-expiration patterns and emulates conventional ventilation profiles.
The system is cost-effective and provides precise breath regulation for small animal respiratory experiments.
Abstract
Small animal experiments are essential in biomedical research, particularly for preclinical investigations. These experiments frequently require mechanical ventilation, but the market offers expensive and functionally limited ventilators. To address this, we developed a cost-effective multi-mode ventilator using commercially available components. Our ventilator utilizes a microcontroller as the primary processing unit, receiving settings from a computer interface. The microcontroller synchronizes five valves to control inspiration and expiration of breathing cycles while managing airflow via piston pumps to generate the required tidal volume. This ensures precise breath regulation in terms of controlling the desired pressure-volume schematic in small animal respiratory systems. Positive end-expiratory pressure is manually adjustable. The system emulates conventional profiles like Volume…
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Taxonomy
TopicsEffects of Environmental Stressors on Livestock · Animal testing and alternatives · Neuroscience of respiration and sleep