Mechanisms of aging in the cardiovascular system: challenges and opportunities
Xiaoying Zhao, Xinyue Yang, Yumeng Lin, Ruolan Lei, Wei Ding, Xinying He, Ying Cao, Dechou Zhang, Ping Liu, Meirou Liang, Zhongyu Han, Yu Jiang
TL;DR
This paper reviews how aging affects the cardiovascular system and contributes to heart disease in older people.
Contribution
The paper provides a comprehensive review of aging mechanisms and their impact on the cardiovascular system.
Findings
Aging alters the cardiac microenvironment through cellular and molecular changes.
Aging contributes to the progression of cardiovascular diseases.
Understanding these mechanisms is crucial for reducing the medical burden of CVDs.
Abstract
Cardiovascular diseases (CVDs) pose a significant threat to the health of the elderly population. As the global population ages and medical management remains imperfect, reducing the medical burden of CVDs is of great importance. Aging is a complex process that contributes to the development and progression of CVDs through various mechanisms. The manuscript reviews the mechanisms of aging and their impact on the cardiovascular system. We explore the role of aging in the cardiac microenvironment, highlighting the changes that occur in the heart’s cellular and molecular landscape as a result of the aging process.
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Click any figure to enlarge with its caption.
Figure 1
Figure 2
Figure 3
Figure 4Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsCardiac Fibrosis and Remodeling · Congenital heart defects research · Genetics, Aging, and Longevity in Model Organisms